Endocrine Abstracts

It has been hypothesized that primary hyperparathyroidism (PH) has a biphasic disease course. During the first phase hypercalcemia is not yet present. Subsequently, the second phase starts with the development of hypercalcemia. In an attempt to identify differences in the calcium regulating hormonal handling in the clinical setting, we evaluated the hormonal responses of gastrin, PTH, phosphate and ionized calcium to oral peptones (a mixture containing L-amino acids with known...

The calcium receptor (CASR) serves as one of the main regulators of the calcium homeostasis. CASR is expressed in among other tissues parathyroid chief cells and kidney tubule cells. It has been hypothesized that CASR gene variations are responsible for low circulating calcium levels together with hypercalciuria and thereby increased risk of kidney stones. The CASR gene polymorphism A986S has been shown associated to elevated serum calcium levels in vivo<...